Abstract

Acute effect of ketone bodies on cognition

Providing protective and possibly alleviating drugs based on ketone bodies to diabetes patients at high risk for cognitive disturbances.

Nicole Jacquline Jensen, Bispebjerg Hospital.

In Alzheimer’s disease, cognitive disturbances are associated with and paralleled by a decrease in cerebral glucose metabolism.

Likewise, hypo-metabolism in the brain is found in pre-diabetic and T2D patients. While waiting for specific treatments to conquer underlying vascular, TAU and beta-amyloid pathologies in dementia, manipulating neuro-energetics seems to be a means of improving neuronal function or even preventing neurodegeneration.

We therefore test the acute effect of ketone bodies on cognition and perfusion with the long-term aim of providing protective and possibly alleviating drugs based on ketone bodies to diabetes patients at high risk for cognitive disturbances.

Tilbage til temaforside